Addressing HLA Typing Errors
Sponsoring Committee: Histocompatibility
Strategic Goal: Promote living donor and transplant recipient safety
Read the policy notice (PDF; 1/2019)
View Board briefing paper (PDF; 12/2018)
Proposal executive summary
The OPTN/UNOS does not have a system for timely reporting and reviewing human leukocyte antigen (HLA) typing errors. Because HLA typing discrepancies are flagged on the donor and recipient histocompatibility forms completed after transplant, there is no timely mechanism for detecting errors in the HLA information used for generating match runs used in organ allocation.
HLA data entry errors, specifically prior to match run generation, can have serious patient safety implications. These HLA typing errors can also create system inefficiencies.
Along with transcriptional errors caused by manual entry of HLA data, another cause of these data entry errors is the setup of HLA data in DonorNet®. A user can unknowingly change a donor’s HLA information prior to the match run, which can result in match runs being executed with the incorrect HLA type.
The Committee is proposing changes to reduce the number of manual HLA data entry errors in UNetSM:
- When HLA data is entered manually into UNet, it must be entered twice (by the same person) for verification of accurate data entry
- When HLA data are uploaded directly into UNet, the member must have a process for verifying that the data are accurate
- Raw HLA typing must be attached in the system for verification of lab results
The Committee believes these changes will increase patient safety by putting more verification processes in place to ensure accurate HLA data is entered into UNet.
Read the proposal (PDF - 200 K; 8/2018)
The Committee welcomes general feedback about this proposal.
Members are asked to comment on both the immediate and long term budgetary impact of resources that may be required if this proposal is approved. This information assists the Board in considering the proposal and its impact on the community.